Follow all of Saturday's NCAA Tournament second round games with USA TODAY Sports' live updates.
Tom Izzo is "Mr. March."
The Michigan State basketball coach has led the Spartans to 28 straight NCAA tournament appearances, with an overall record of 60-26 in March Madness games.
On Saturday, he'll have a chance at his 17th Sweet 16.
The No. 3 seed Spartans will have to get through No. 6 Louisville first in Saturday's East Region second round game in Buffalo.
The Cardinals will once again be without star freshman point guard Mikel Brown Jr. A back injury kept him out of Louisville's first round win over South Florida and will keep him sidelined through the tournament's first weekend.
Louisville led comfortably for most of its win over USF until some late, nervy moments. Isaac McKneeley led the Cardinals with 23 points, which included going 7-of-10 from behind the arc. As a whole, Louisville shot 52% from behind the arc. The Cardinals will need that type of hot shooting to knock off the usually rugged Spartans.
Here's what you need to know for today's second round showdown:
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Michigan State to the Sweet 16 with win over Louisville
Coen Carr had 21 points and 10 rebounds to lead four Michigan State players in double figures, and Jeremy Fears added 12 points and a school NCAA tournament record 16 assists as the Spartans advanced to the Sweet 16 with a 77-69 win over Louisville.
The Spartans, the East Region’s No. 3 seed, used hot shooting beyond the arc in the first half and used spurts of 8-0 and 7-0 to take an early 10-point lead.
Louisville, who played without Mikel Brown, Jr., out with a back injury, hung around as Michigan State was sloppy with the ball, as the Spartans, who averaged 11.5 turnovers a game, turned it over 12 times in the first half, and took a 36-31 lead into the break.
The Cardinals (24-10) relied on the three-point ball all season long but were betrayed by the rim, hitting only 13-36 from downtown and shooting 41% for the game.
Michigan State used a 13-3 run in the second half, capped by Jaxon Kohler’s 3-pointer, which gave the Spartans their biggest lead at 63-50. Trey Fort had 12 points and Kohler had 10 for Michigan State, who had 21 assists on 25 made field goals.
Fears recorded his second straight game with 10 assists in this year's NCAA Tournament, setting a Big Ten record.
Ryan Conwell scored 21 points, and Adrian Wooley added 17 points for Louisville. Isaac McKneely, who hit seven three-pointers and scored 23 points in the Cardinals’ first-round victory against South Florida, had only nine points.
Michigan State (27-7) advances to the East Regional in Washington, D.C. and will play the winner of UConn and UCLA on Friday.
Louisville inching back in game
Louisville won't go away as every time Michigan State pushes the lead near double figures, the Cardinals improved shooting gets them back in the game. Aly Khalifa hit a three point to cut the lead to three, but Trey Fort answered with a three of his own on the Spartans next possession.
Michigan State carelessness with ball keeping Louisville in game
Michigan State center Coen Carr started the second half with his own dunk fest, taking an alley-oop for one basket and a highlight breakaway slam to push the lead to 42-33. Carr has 11 points and has added seven rebounds. The Spartans average 11.5 turnovers a game, and they have already coughed the ball up 12 times with more than 15 minutes left in regulation.
Halftime: Michigan State 36, Louisville 31
In the first half of runs, Michigan State used spurts of 9-0 and 8-0 to take a 36-31 lead at halftime over Louisville in the second round of the East Region.
The Cardinals fell behind by 10, but despite missing at one point 10 of 11 shots, they used a 7-0 run of their own to get back in the game.
The up-and-down pace is expected as Louisville used 10 players and Michigan State played nine in the first half.
Adrian Wooley had nine points, and Ryan Conwell added nine points and four rebounds for Louisville, who shot 36% and went 4-18 from 3-point land. Coen Carr led the Spartans’ balanced scoring attack with seven points and seven rebounds as they went more than four minutes without a point before Trey Fort’s four-point play to push the lead back up to eight with 3:46 left.
Michigan State shot 46 percent in the first half and had 12 assists on its 13 made field goals.
Starting lineups
Louisville
G - J'Vonne Hadley
G - Ryan Conwell
G - Isaac McKneely
G - Adrian Wooley
F - Vangelis Zougris
Michigan State
G - Jeremy Fears Jr.
F - Jaxon Kohler
F - Jordan Scott
F - Coen Carr
C - Carson Cooper
Michigan State vs Louisville live score
| TEAMS | 1H | 2H | F |
| Louisville | 31 | 38 | 64 |
| Michigan St | 36 | 39 | 74 |
What time is Michigan State vs Louisville?
- Time: 2:45 p.m. ET, Saturday.
What channel is Michigan State vs Louisville? Streaming, how to watch
- The game is airing on CBS and streaming on Paramount+.
Michigan State vs Louisville prediction, live odds
- Ehsan Kassim: Michigan State
- Jordan Mendoza: Michigan State
- John Leuzzi: Michigan State
- Blake Schuster: Michigan State
- Moneyline: Michigan State (-210); Louisville (+170)
- Spread: Michigan State (-4.5)
- Over/under total: 151.5
Mikel Brown Jr. injury update: Will Louisville star play today vs Michigan State?
Prior to the Cardinals' first round game against South Florida, Louisville announced Brown wouldn't play in the opener and would also miss the second round game, should they advance.
Brown, who's projected to be an NBA lottery pick later this year, has been sidelined for the Cardinals' past five games (and 13 total this season). Pat Kelsey said Brown re-aggravated a back injury, which surfaced in mid-December, by taking some hard falls during a Feb. 23 loss at then-No. 19 North Carolina.
This article originally appeared on USA TODAY: Michigan State vs Louisville score: Spartans are into the Sweet 16 again