For the Denver Broncos, irrepressible optimism was replaced by exorbitant doubt in a matter of moments.
The Broncos will have to continue their journey through the AFC Championship Game, and potentially beyond, without starting quarterback Bo Nix. It was announced shortly after Denver’s 33-30 AFC divisional-round win over the Buffalo Bills that Nix had broken his ankle on one of the game’s final plays.
The injury means backup quarterback Jarrett Stidham will be asked to start at home against the New England Patriots with a Super Bowl berth on the line. Denver entered the postseason as the AFC’s No. 1 seed and owns an 8-1 home record this season. But the sudden change at quarterback has made the Patriots 5.5-point favorites and dramatically shifted the outlook of the Broncos’ season.
It is not the first time across sports that a late-season injury to a key player has significantly altered championship hopes. In some cases, backups stepped in and saved the day.
In Week 14 of the 2017 NFL season, Philadelphia Eagles quarterback Nick Foles came in for injured MVP candidate Carson Wentz and finished the journey through a Super Bowl win over the New England Patriots.
In 1990, Jeff Hostetler took over for New York Giants starting quarterback Phil Simms, who broke his foot in Week 15. Five wins and one precariously wide-right kick from Buffalo Bills kicker Scott Norwood later, Hostetler and the Giants were Super Bowl champions.
Unfortunately, it doesn’t always work out. Here are 10 examples across sports in which a major injury changed a team’s fortune. Let us know in the comments which ones we missed.
Kevin Durant and Klay Thompson, 2019 Golden State Warriors
The Golden State Warriors suffered a double whammy in the 2019 NBA Finals. With the Warriors trailing the series 3-1 entering Game 5, Durant tore his Achilles after just 12 minutes of court time. Golden State managed to win the game to stay alive, but then Klay Thompson tore his ACL in Game 6. Without the team’s second- and third-leading scorers that season, the Warriors lost the finals 4-2 to the Toronto Raptors.
By the start of the next season, Durant was with the Brooklyn Nets. Thompson would miss the entire season, and Stephen Curry played only five games after breaking his left hand.
Kenyon Martin, 1999-2000 Cincinnati Bearcats
The Bearcats were 28-2, ranked No. 1, and in Martin had the national player of the year and eventual No. 1 NBA Draft pick by the New Jersey Nets. But the big man broke his fibula in the Conference USA Tournament. UC was dropped to a No. 2 seed, then lost in the second round of the 2000 NCAA Tournament, 69-61, to Tulsa.
Martin had led the conference in scoring (18.9 points per game) and blocks (3.5), while adding 9.7 rebounds. Without Martin, the Bearcats were outrebounded 39-34 in their tournament loss to the Golden Hurricane.
Kyrie Irving, 2015 Cleveland Cavaliers
The Cavs’ All-Star point guard fractured his kneecap in Game 1 of the 2015 NBA Finals, the first of four straight finals matchups between the Cavaliers and Warriors.
In the prior series, Kevin Love suffered a severe left shoulder injury against the Boston Celtics that knocked him out of the finals as well. Though LeBron James tried to carry the load alone, the absence of the team’s second- and third-leading scorers and leading rebounder was too much even for James to overcome.
The Warriors went on to win the series in six games, their first of four titles in the Steph Curry-Steve Kerr era.
Tyrese Haliburton, 2025 Indiana Pacers
Haliburton was the Pacers’ best player in the 2025 playoffs, taking Indiana to Game 7 of the NBA Finals against the favored Oklahoma City Thunder.
But he was playing with a strained right calf that he suffered in Game 5, and it proved to be a ticking time bomb. After catching fire and hitting three triples in the first seven minutes of Game 7, his calf gave out on a drive, and he tore his Achilles.
As Haliburton left the court in tears, the Pacers were trailing only 18-16. Oklahoma City went on to win 103-91 to take the series.
Colt McCoy, 2009-10 Texas Longhorns
Texas’ starting quarterback, a first-team All-American, suffered a pinched nerve in his throwing shoulder in the first quarter of the 2010 national championship game against Alabama.
McCoy had finished third in Heisman voting that season, but freshman Garrett Gilbert had to replace him, and Texas lost 37-21 to a Crimson Tide squad led by Heisman winner Mark Ingram.
Juju Watkins, 2025 USC Trojans
USC was a No. 1 seed in the 2025 NCAA Women’s Tournament when Watkins tore her ACL against Mississippi State in the second round. Watkins was fourth in the nation in scoring that season, averaging 23.9 points per game. She won AP player of the year and was named a first-team AP All-American after leading USC to a Big Ten title.
Without her, the Trojans managed to dispatch the Bulldogs 96-59 and advanced to the Elite Eight, where they lost to eventual champion UConn, 78-64.
Jim Rice, 1975 Boston Red Sox
The Red Sox had two leading contenders for AL Rookie of the Year in 1975, future Hall of Famer Jim Rice and outfielder Fred Lynn. Lynn took home rookie of the year and AL MVP, the first to win both in the same year, but Rice was stellar that season as well. He hit 22 home runs with a .309 batting average, .350 on-base and .491 slugging percentage.
In late September, Rice broke his hand after being hit by a pitch against the Detroit Tigers. He missed the rest of the season, including the entire postseason. In his absence, the Red Sox made the Fall Classic, but lost to the Cincinnati Reds in an exhilarating seven-game series coined “the series that saved baseball.”
The defeat also furthered the “Curse of the Bambino,” as Boston had remained without a championship since selling Babe Ruth to the New York Yankees following the 1919 season. The World Series could not break the curse until 2004.
Brock Purdy, 2022-23 San Francisco 49ers
Purdy’s improbable rookie season ended at the worst time, with a UCL injury in the first quarter of the 2023 NFC Championship Game against the Eagles, which the 49ers lost 31-7. The Mr. Irrelevant pick, taken last in the 2022 NFL Draft, had fought his way up from the practice squad to take over starting duties that season in Week 13 after Trey Lance and Jimmy Garoppolo suffered major injuries.
Purdy had won seven consecutive games, including the first two rounds of the playoffs, before being forced to exit the NFC Championship Game. Josh Johnson was tabbed to finish the game but suffered a concussion in the third quarter, which, for a brief moment, had running back Christian McCaffrey readying a helmet with a radio before Purdy returned. Purdy was unable to throw, however, and simply had to hand the ball off for the remainder of the game.
Carey Price, 2013-14 Montreal Canadiens
The Canadiens goaltender suffered a knee injury when New York Rangers forward Chris Kreider crashed into him in Game 1 of the 2014 Eastern Conference final. Price was out for the rest of the series, and the Canadiens lost the series 4-2.
Price had career bests in games played (59), wins (34), goals-against average (2.32) and save percentage (.927) that season. Without him for much of the series, the Rangers peppered the Montreal net for 23 goals over six games, an average of 3.83 per contest.
Derrick Rose, 2011-12 Chicago Bulls
Chicago’s point guard was on top of the basketball world entering the 2012 NBA playoffs. Chicago was the No. 1 seed, and Rose was one year removed from being the youngest MVP in NBA history.
But he tore his ACL in Game 1 of the first-round series against the eighth-seeded Philadelphia 76ers. Without its MVP, Chicago lost the series 4-2, and Rose’s career never fully recovered. Since then, the Bulls have only been to the playoffs five times and have only won two playoff series.
This article originally appeared in The Athletic.
Montreal Canadiens, Denver Broncos, San Francisco 49ers, Chicago Bulls, Cleveland Cavaliers, Indiana Pacers, Golden State Warriors, Los Angeles Lakers, Texas Longhorns, Cincinnati Bearcats, USC Trojans, NHL, NFL, NBA, MLB, College Football, Men's College Basketball, Women's College Basketball
2026 The Athletic Media Company