49ers running back Isaac Guerendo became the team's starter last week and the rookie scored two touchdowns against the Bears, but his day ended on a down note.
Thursday Night Football continues tonight with the Los Angeles Rams vs. San Francisco 49ers on Prime Video. Here's everything you need to know about how to watch tonight's game.
Dolphins quarterback Tua Tagovailoa heads into Week 15 with the highest completion percentage in the league and one of the highest single-season completion percentages of all time.
The Rams pulled a major upset when they defeated the 49ers earlier this season minus star receivers Puka Nacua and Cooper Kupp, who will play Thursday.
Brad Thomas, Eric Froton and Vaughn Dalzell analyze the 12-team College Football Playoff and share which teams they think can win it all, including Penn State and Boise State, two teams with easier paths to the final.
Brad Thomas, Eric Froton and Vaughn Dalzell look ahead to one of the best rivalries in college football and analyze whether Navy will be able to upset Army and earn the Commander-in-Chief's Trophy.
Brad Thomas, Eric Froton and Vaughn Dalzell analyze if Alabama or Ole Miss should have made the 12-team College Football Playoff over SMU and debate whether the playoff should expand to 16 teams next season.
49ers president of football operations and general manager John Lynch explained to Greg Papa on NBC Sports Bay Area's "49ers Game Plan" why San Francisco will have its hands full against Los Angeles Rams quarterback Matthew Stafford on "Thursday Night Football."